Cancer Genomics
2025-06-188 min
Liquid biopsy advances in early-stage cancer detection
Circulating tumor DNA analysis is reshaping how clinicians detect malignancies before symptoms emerge.
Read article →Scientific Blog
Research insights & scientific perspectives
Peer-reviewed commentary on cancer genomics, next-generation sequencing, bioinformatics, RNA biology, precision medicine, and artificial intelligence in healthcare.
Cancer Genomics
2025-05-2210 min
Mutational signatures as therapeutic roadmaps in solid tumors
Deciphering mutational processes opens new avenues for targeted intervention and patient stratification.
Read article →Cancer Genomics
2025-04-107 min
Tumor microenvironment heterogeneity and immune evasion
Single-cell profiling reveals how cancer cells sculpt their niche to suppress immune surveillance.
Read article →NGS
2025-06-129 min
Long-read sequencing closes the gap in structural variant detection
PacBio and Oxford Nanopore platforms are now routine tools for resolving complex genomic rearrangements.
Read article →NGS
2025-05-056 min
Whole-genome sequencing in newborn screening programs
Pilot studies demonstrate the clinical utility and ethical complexities of early-life genomic data.
Read article →NGS
2025-03-288 min
Optimizing library prep for low-input tumor samples
Ultra-low DNA inputs demand refined protocols to maintain sensitivity without introducing artifacts.
Read article →Bioinformatics
2025-06-057 min
Scalable cloud pipelines for population-scale genomics
Containerized workflows on Kubernetes enable reproducible analysis of hundred-thousand cohorts.
Read article →Bioinformatics
2025-04-309 min
Benchmarking variant callers across diverse ancestries
Reference bias persists; multi-ethnic truth sets are essential for equitable genomic medicine.
Read article →Bioinformatics
2025-02-1411 min
Graph genomes and the future of reference assemblies
Linear references are giving way to pangenome graphs that capture population diversity natively.
Read article →RNA Biology
2025-06-018 min
Single-cell RNA-seq reveals lineage plasticity in leukemia
Transcriptomic trajectories trace differentiation reversals that underlie relapse and resistance.
Read article →RNA Biology
2025-04-186 min
Circular RNAs as emerging biomarkers in cardiovascular disease
CircRNAs exhibit remarkable stability in plasma, making them attractive non-invasive diagnostic candidates.
Read article →RNA Biology
2025-03-0510 min
Nascent transcript profiling with precision run-on sequencing
PRO-seq maps active promoters and enhancers with nucleotide resolution in living cells.
Read article →Precision Medicine
2025-05-287 min
Pharmacogenomic testing in oncology clinical workflows
Integrating germline pharmacogenes into electronic health records streamlines therapeutic decision-making.
Read article →Precision Medicine
2025-04-089 min
Polygenic risk scores for common disease prevention
Combining millions of common variants into risk estimates is transitioning from research to clinical utility.
Read article →Precision Medicine
2025-02-228 min
Rare disease diagnostics through trio-based exome analysis
Family trios remain the gold standard for resolving de novo and compound heterozygous variants.
Read article →AI in Healthcare
2025-06-1010 min
Foundation models for clinical variant interpretation
Large language models trained on genomic literature are accelerating variant pathogenicity assessment.
Read article →AI in Healthcare
2025-05-158 min
Deep learning predicts patient response to immunotherapy
Multi-modal neural networks fuse pathology imaging, transcriptomics and clinical history for outcome prediction.
Read article →AI in Healthcare
2025-03-209 min
Generative models for de novo protein design in therapeutics
Diffusion-based architectures propose novel protein binders with predicted high affinity and manufacturability.
Read article →Stay current with genomic science
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